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KMID : 0388220140210020074
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Journal of the Korean Rheumatism Association
2014 Volume.21 No. 2 p.74 ~ p.76
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A Case of Refractory Headache with Antiphospholipid Antibody Syndrome Improved by High-Intensity Warfarin Medication
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Cho Kyung-Hee
Yang Jun-Gyu
Kim Ji-Sun
Lee Sung-Woog
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Abstract
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Antiphospholipid antibody syndrome (APS) is a coagu-lation disorder associated with antiphospholipid antibodies. Headache is common in APS patients and often un-responsive to analgesics. We report a case of refractory headache in a patient with APS, who was improved by high-intensity warfarin treatment. The mechanisms of the headache in patients with APS were presumed to be hyper-coagulability of microcirculation and thrombotic occlusion of the capillaries, which were associated with anti-phospholipid antibodies. Therefore, high-intensity warfarin could be considered as one of the treatments for refractory headache in patients with APS.
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KEYWORD
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Antiphospholipid antibody syndrome, Headache, Warfarin
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